Journal article

Synthesis of simplified analogues of eleutherobin via a Claisen rearrangement/RCM strategy

SY Frankie Mak, GCH Chiang, JEP Davidson, JE Davies, A Ayscough, G Pain, JW Burton, AB Holmes

Tetrahedron Asymmetry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009

Abstract

The enantioselective synthesis of a number of simplified analogues of the cytotoxic natural product eleutherobin is reported. © 2009 Elsevier Ltd. All rights reserved.

University of Melbourne Researchers

Grants

Awarded by GlaxoSmithKline


Funding Acknowledgements

We thank the Royal Society for the award of a University Research Fellowship (J.W.B.), Universities UK and the Cambridge Commonwealth Trust (Studentship to S.Y.F.M.), GSK (studentship to J.E.P.), British Biotech (studentship to G.C.H.C.) and the EPSRC for generous financial support, including financial assistance towards the purchase of the Nonius CCD diffractometer, and provision of the Swansea National Mass Spectrometry Service. We thank the ARC (Grant No. FF0348471), VESKI and CSIRO for support.